Angelo D'Alessandro Selected Research

Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)

1/2021	G6PD activity contributes to the regulation of histone acetylation and gene expression in smooth muscle cells and to the pathogenesis of vascular diseases.
1/2020	Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methylation.
1/2020	CRISPR-Mediated Single Nucleotide Polymorphism Modeling in Rats Reveals Insight Into Reduced Cardiovascular Risk Associated With Mediterranean G6PD Variant.
11/2018	The clinical impact of glucose-6-phosphate dehydrogenase deficiency in patients with sickle cell disease.

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Angelo D'Alessandro Research Topics

Disease

39	Neoplasms (Cancer) 03/2024 - 10/2013
34	Hemolysis 03/2024 - 01/2016
34	Hypoxia (Hypoxemia) 01/2024 - 01/2016
29	Inflammation (Inflammations) 12/2023 - 03/2010
21	Wounds and Injuries (Trauma) 05/2024 - 12/2014
15	Sickle Cell Anemia (Hemoglobin S Disease) 03/2024 - 01/2017
15	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 03/2023 - 10/2016
14	COVID-19 02/2024 - 01/2020
13	Infections 12/2022 - 01/2012
11	Leukemia 12/2021 - 11/2018
11	Hemorrhagic Shock 01/2020 - 12/2014
9	Shock 03/2024 - 05/2015
9	Obesity 01/2024 - 12/2018
8	Pulmonary Hypertension 01/2023 - 10/2016
8	Glucosephosphate Dehydrogenase Deficiency 01/2023 - 01/2017
7	Hemorrhage 12/2023 - 05/2015
7	Breast Neoplasms (Breast Cancer) 12/2023 - 11/2015
6	Pancreatic Neoplasms (Pancreatic Cancer) 03/2024 - 09/2011
5	Squamous Cell Carcinoma of Head and Neck 03/2024 - 11/2022
5	Anemia 02/2024 - 01/2021
5	Neoplasm Metastasis (Metastasis) 12/2023 - 11/2015
5	Mitochondrial Diseases (Mitochondrial Disease) 11/2023 - 01/2021
5	Insulin Resistance 01/2022 - 06/2016
4	Asthma (Bronchial Asthma) 04/2024 - 01/2021
4	Adenocarcinoma 03/2024 - 12/2019
4	Hypertension (High Blood Pressure) 01/2022 - 10/2019
4	beta-Thalassemia (Cooley's Anemia) 01/2022 - 03/2021
3	Critical Illness (Critically Ill) 01/2024 - 07/2017
3	Fibrosis (Cirrhosis) 02/2023 - 12/2018
3	Melanoma (Melanoma, Malignant) 01/2023 - 01/2021
3	Thalassemia 01/2023 - 11/2018

Drug/Important Bio-Agent (IBA)

26	Proteins (Proteins, Gene)FDA Link 01/2024 - 06/2014
19	Fatty Acids (Saturated Fatty Acids)IBA 03/2024 - 09/2011
19	Amino Acids FDA Link 02/2023 - 06/2015
16	LipidsIBA 03/2024 - 06/2014
16	EnzymesIBA 08/2023 - 09/2011
15	Oxygen (Dioxygen)IBA 01/2024 - 01/2016
15	Glucose (Dextrose)FDA LinkGeneric 01/2024 - 08/2015
15	CytokinesIBA 10/2023 - 10/2016
14	Hemoglobins (Hemoglobin)IBA 02/2024 - 01/2016
14	Lactic Acid (Lactate)FDA LinkGeneric 01/2023 - 06/2014
13	Succinic Acid (Succinate)IBA 01/2023 - 12/2016
12	purineIBA 08/2023 - 06/2014
9	Biomarkers (Surrogate Marker)IBA 04/2024 - 01/2016
9	CarbonIBA 12/2023 - 04/2015
9	Choline (Choline Chloride)IBA 12/2022 - 01/2019
9	Glutathione (Reduced Glutathione)IBA 01/2021 - 06/2014
8	NitrogenIBA 02/2024 - 04/2015
8	KynurenineIBA 11/2023 - 11/2015
8	Carboxylic AcidsIBA 01/2023 - 08/2015
8	C-Reactive ProteinIBA 12/2022 - 01/2019
8	Oxidants (Oxidizing Agents)IBA 10/2021 - 01/2016
7	Carnitine (L-Carnitine)FDA LinkGeneric 03/2024 - 11/2020
7	HypoxanthineIBA 01/2024 - 01/2018
7	Pyruvic Acid (Pyruvate)IBA 02/2023 - 07/2017
6	Complement System Proteins (Complement)IBA 05/2024 - 01/2019
6	RNA (Ribonucleic Acid)IBA 03/2024 - 01/2020
6	Arginine (L-Arginine)FDA Link 12/2023 - 10/2016
6	venetoclaxIBA 03/2023 - 12/2018
6	ProteomeIBA 01/2023 - 12/2014
6	IronIBA 01/2023 - 01/2019
6	Tryptophan (L-Tryptophan)FDA Link 11/2022 - 01/2019
6	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 11/2022 - 01/2016
6	Glutamine (L-Glutamine)FDA Link 11/2022 - 01/2016
5	Pyruvate KinaseIBA 03/2024 - 12/2017
5	Urea (Carbamide)FDA LinkGeneric 02/2024 - 01/2020
5	Adenosine Triphosphate (ATP)IBA 01/2024 - 01/2019
5	2,3-Diphosphoglycerate (2,3 Bisphosphoglycerate)IBA 01/2024 - 10/2016
5	Bile Acids and Salts (Bile Acids)IBA 12/2023 - 05/2015
5	CollagenIBA 02/2023 - 01/2017
5	AntioxidantsIBA 05/2022 - 06/2014
5	NADP (NADPH)IBA 01/2021 - 09/2011
4	PolyaminesIBA 03/2024 - 06/2015
4	Adenosine (Adenocard)FDA LinkGeneric 10/2023 - 08/2016
4	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2023 - 12/2016
4	Azacitidine (5 Azacytidine)FDA Link 03/2023 - 12/2018
4	Uric Acid (Urate)IBA 02/2023 - 06/2015
4	Oxidoreductases (Dehydrogenase)IBA 01/2023 - 01/2016
4	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2023 - 10/2016
4	Phosphates (Orthophosphate)IBA 11/2022 - 01/2018
4	SerpinsIBA 03/2021 - 03/2010
4	IsotopesIBA 01/2021 - 12/2016
4	Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)IBA 01/2021 - 11/2018
3	malic acid (malate)IBA 03/2024 - 10/2022
3	fibrin fragment D (D-dimer)IBA 02/2024 - 01/2021
3	durvalumabIBA 01/2024 - 11/2022
3	CeramidesIBA 12/2023 - 01/2018
3	Cysteine (L-Cysteine)FDA Link 12/2023 - 01/2019
3	Equilibrative Nucleoside Transporter 1IBA 10/2023 - 01/2017
3	SolutionsIBA 09/2023 - 01/2021
3	Sickle HemoglobinIBA 02/2023 - 01/2022
3	Triglycerides (Triacylglycerol)IBA 02/2023 - 12/2018
3	FumaratesIBA 01/2023 - 01/2017

Therapy/Procedure

31	Therapeutics 03/2024 - 08/2016
8	Resuscitation 11/2022 - 05/2015
7	Drug Therapy (Chemotherapy) 12/2023 - 01/2018
5	Immunotherapy 03/2024 - 01/2019
5	Precision Medicine 12/2023 - 01/2017
4	Radiotherapy 03/2024 - 01/2023
3	Mechanical Ventilators (Ventilator) 09/2023 - 11/2022